Hepatoprotective effect of Foeniculum vulgare essential oil: A carbon-tetrachloride induced liver fibrosis model in rats

  • Hanefi Özbek Departments of Pharmacology, Faculty of Medicine, Yüzüncü Yil University
  • Serdar Ugras Department of Pathology, Faculty of Medicine, Yüzüncü Yil University
  • Irfan Bayram Department of Pathology, Faculty of Medicine, Yüzüncü Yil University
  • Ismail Uygan Department of Gastroenterology, Faculty of Medicine, Yüzüncü Yil University
  • Ender Erdogan Department of Histology, Faculty of Medicine, Yüzüncü Yil University, Turkey.
  • Abdurrahman Öztürk Department of Histology, Faculty of Medicine, Yüzüncü Yil University
  • Zübeyir Huyut Departments of Pharmacology, Faculty of Medicine, Yüzüncü Yil University
Keywords: Foeniculum Vulgare Miller, Fennel essential oil, FEO, Carbon tetrachloride, Liver fibrosis, Hepatoprotective effect.

Abstract

Hepatoprotective activity of Foeniculum vulgare (fennel) essential oil was studied using a carbon tetrachloride-  induced liver fibrosis model in rats. The hepatotoxicity produced by chronic carbon tetrachloride administration  was found to be inhibited by Foeniculum vulgare essential oil with evidence of decreased levels of  serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. Histopathological  findings also suggest that Foeniculum vulgare essential oil prevents the development of chronic liver  damage. The changes in body weights in the rats assigned to the study groups supported these biochemical  and histopathological findings. The results of this study clearly indicate that Foeniculum vulgare essential oil  has a potent hepatoprotective action against carbon tetrachloride-induced liver fibrosis in rats. 

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