The effects of line crossing following selection in mice

  • A Wolc Department of Animal Science, Iowa State University and Hy-Line International, Dallas Center
  • W Schlocte Berlin
  • T Szwaczkowski Department of Genetics and Animal Breeding, Poznan University of Life Sciences


The objective of this study was to evaluate selection responses and heterotic effects in mouse line crosses after ten generations of selection. Four mouse lines were analyzed: G, L, W and C, selected for growth (body weight at 42 days [BW42]), tail length at 42 days [TL], litter size at birth [LS], and the control line, respectively. After 10 generations of selection the first set of crosses was created; in generation 12, backcrosses and three-way crosses were made. In the crosses the following traits were analyzed: