Technical Report: Technique of Bladder Catheterization in Female Mice and Rats for Intravesical Instillation in Models of Bladder Cancer

  • P A Oliveira Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro
  • M J Pires Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro
  • C Nóbrega Agrarian School of Viseu- Polytechnic Institute of Viseu (IPV)
  • R Arantes-Rodrigues Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro
  • A M Calado Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro
  • J Carrola Departament of Environmental and Biological Enginnering, CITAB, University of Trás-os-Montes and Alto Douro
  • M Ginja Department of Veterinary Sciences, CITAB, University of Trás-os-Montes and Alto Douro
  • A Colaço Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro

Abstract

Animal models offer a system that enables a better understanding of basic biological questions. Urinary bladder catheterization is a common procedure in models of female urothelial tumours and yet the technique does still need to be described further. The methods described in the existing literature do not outline how the procedure should be adapted for different research goals. In this report, we describe systematically catheterization of female mice and rats as well as analysing several anaesthetic protocols, which can be used to carry out this technical procedure.
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