Animal Models in Peritoneal Dialysis

  • B Stojimirovic Clinic of Nephrology, Institute of Urology and Nephrology, Clinical Center of Serbia, Belgrade
  • J Trbojevic-Stankovic Department of Hemodialysis, Center for Urology, Clinical Center Dr Dragisa Misovic, Belgrade
  • D Nesic Institute of Medical physiology, School of Medicine, University of Belgrade, Belgrade


Over the last decades peritoneal dialysis (PD) has become a successful and widely used treatment for endstage  renal disease patients worldwide. Together with the increasing number of uremic patients successfully  treated with PD has grown an interest in physiological, pathophysiological and clinical aspects of this  therapeutic method. This article provides an overview of the current status on animal models used in studying  the histology and physiology of the peritoneum, as well as the process of peritoneal dialysis itself. We  discuss species of experimental animals, methods of peritoneal access, sampling for histology, different  techniques and methodologies, and complications of experimental models of PD.