Correlation Between The Erythrocyte Sedimentation Rate and Blood Nitric Oxide Levels in Rabbits?

  • Metehan Uzun Department of Physiology, Faculty of Veterinary Medicine, University of Kafkas, Kars
  • Sinan Saral Department of Biochemistry, Faculty of Veterinary Medicine, University of Kafkas, Kars
  • Onur Atakisi Department of Biochemistry, Faculty of Veterinary Medicine, University of Kafkas, Kars
  • Kursad Yapar Department of Pharmacology-Toxicology, Faculty of Veterinary Medicine, University of Kafkas, Kars
  • Erdogan Uzlu Department of Internal Medicine, Faculty of Veterinary Medicine, University of Kafkas, Kars
  • Mehmet Citil Department of Internal Medicine, Faculty of Veterinary Medicine, University of Kafkas, Kars
  • Didem Tastekin Department of Internal Medicine, Faculty of Medicine, University of Kafkas, Kars
  • Hidayet Metin Erdogan Department of Internal Medicine, Faculty of Veterinary Medicine, University of Kafkas, Kars

Abstract

This study was designed to determine whether elevated or decreased blood nitric oxide (NOx) values following  injections of L-arginine and N_-nitroarginine methylester (L-NAME) are positively correlated with  the erythrocyte sedimentation rate (ESR) in healthy rabbits. The study involved 21 New Zealand rabbits of  both sexes, aged between 10 and 15 months old. They were divided into 3 equal groups. The control group  received 1 ml isotonic saline per rabbit, and Groups I and II received 100 mg/kg L-NAME and 250 mg/kg  L-arginine intraperitoneally, respectively. After two hours blood samples were obtained and ESR (30, 60,  and 120 minutes) and NOx were estimated. There were no significant differences between the ESR values  at all times; however significant correlation between the NOx and ESR existed in Group II at 2 hours after  injection. In conclusion, there was a positive correlation between high blood NOx and ESR values, but  detailed studies are needed to disclose this correlation. 

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